This Work Package (WP) will develop new single-photon detectors, compact laser systems and fast timing circuits for building an integrated smart optode. The latter will be incorporated in ultrasound probes for combing optical tomography and ultrasound elastography for the classification of breast lesions. WP1 will lead to:
The main objective of WP2 is to provide the measurement strategies, algorithms, and software for optical characterization of breast lesions using ultrasound (US) priors. More specifically, WP2 will:
The objective of this work package is to conceive and build up a new multi-modal system presenting the combined functions of US imaging, Shear Wave Elastography (SWE) map and optical imaging. This system will be implemented on an US/SWE Aixplorer from SSI. In order to carry out this integration a new handheld imaging probe combining US transducer and the innovative optical subunits developed in WP1 will have to be designed and developed. This new probe will be linked to a global optical/US acquisition mock-up for which synchronisation and control software will be developed. A processing software integrating the dedicated algorithms for optical acquisitions and co-registration optical/us information developed in WP2 will be designed and integrated.
The specific aims are to:
The main objective of Work Package 4 is to validate each new photonic component, the single optode and then the whole SOLUS prototype on tissue-mimicking optical/ultrasound phantoms by following suitable protocols for performance assessment of diffuse optical systems. More specifically, WP4 will lead to:
The objective of this WP is to develop clinical protocols, obtain ethical approvals and test the multi-modal SOLUS system in real-settings, in terms of its usability and integration into the clinical and radiologist work-flow for breast nodule characterization, and to carry out a pilot study to evaluate it on real benign and malignant breast nodules.
Specifically, this work package will:
The main objective of WP6 is to develop, coordinate and pursue the overall communication and dissemination strategy and activities for SOLUS. Input to this horizontal WP will be required from all partners. WP6 is tasked with:
The main objective of work package 7 is to prepare the commercial exploitation of the results of the SOLUS project. The results include the developed system, the subcomponents of the system or the knowledge that was generated during the course of the project. More specifically, the WP7 will document the key attributes of the potential products and services derived from the project to support the decision of creating, developing and commercialising them.
The objectives of WP7 are to:
Work Package 8 is tasked with the overall project coordination and management of SOLUS. WP8 will: